Ibuprofen (Rheuxan)

Description:
For the relief of mild to moderate pain including rheumatic or muscular pain, pain of non-serious arthritic conditions, backache, headache, dental pain, migraine, neuralgia, dysmenorrhoea, feverishness and for the relief of symptoms of colds and influenza. For oral administration and short-term use only.

Product Description:

Ibuprofen (Rheuxan) 400mg Tablets are a type of nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It works by blocking the production of certain chemicals in the body (prostaglandins) that cause pain and inflammation. Ibuprofen (Rheuxan) 400mg tablets are often used to treat conditions like headaches, toothaches, muscle aches, arthritis, menstrual cramps, and fever.

Each tablet of Ibuprofen (Rheuxan) contains 400mg of Ibuprofen, and the packaging contains 100 tablets, making it suitable for both short-term and longer-term use for pain and inflammation management.

Key Features:

• Active Ingredient: Ibuprofen 400mg.

• Formulation: Tablet, for oral administration.

• Mechanism of Action: Reduces inflammation, pain, and fever by inhibiting the enzymes cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), which are involved in the synthesis of prostaglandins.

• Indications: Used to treat pain (headaches, muscle pain, menstrual cramps, etc.), inflammation (arthritis, tendinitis), and fever.

• Packaging: Available in a 100-tablet pack.

Indications:

Ibuprofen (Rheuxan) 400mg tablets are indicated for the following conditions:

1. Pain Relief:

   • Acute and chronic pain conditions like headaches, toothaches, muscle pain, joint pain, back pain, and menstrual cramps.

2. Inflammation:

   • Used to treat inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and other inflammatory disorders.

3. Fever:

   • Reduces fever associated with various conditions, including cold and flu, infections, or post-vaccination fever.

4. Post-Surgical Pain:

   • Can be used to manage mild to moderate post-surgical pain, in combination with other pain management strategies.

5. Musculoskeletal Disorders:

   • Treatment for conditions like tendinitis and bursitis.

Dosage:

The recommended dosage of Ibuprofen (Rheuxan) 400mg tablets is as follows, but always follow your healthcare provider’s instructions:

• For Adults:

  • The usual dose for pain or fever is 400mg every 4 to 6 hours as needed. The maximum daily dose should not exceed 3200mg (8 tablets of 400mg) in a 24-hour period.

• For Rheumatoid Arthritis/Osteoarthritis:

  • The typical dose is 400mg to 800mg every 6 to 8 hours depending on the severity of the condition. The maximum dose should be 3200mg daily, divided into 3-4 doses.

• For Menstrual Cramps:

  • Start with a dose of 400mg, followed by additional doses of 200-400mg every 4-6 hours if necessary, up to the maximum daily dose of 3200mg.

• For Children:

  • The dosage for children is based on body weight, typically around 5-10mg/kg every 6-8 hours, not exceeding 40mg/kg per day. A child weighing 20 kg (44 lbs) may take 200-400mg per dose.

Administration:

• Take the tablet with food or milk to reduce stomach irritation.

• Swallow the tablet whole with a glass of water. Do not chew or crush the tablet.

• Ensure you do not exceed the recommended dose, and avoid taking multiple doses simultaneously.

Missed Dose: If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. Do not take two doses to make up for a missed one.

Side Effects:

Common side effects of Ibuprofen (Rheuxan) 400mg tablets include:

• Upset stomach, nausea, or heartburn.

• Dizziness or headache.

• Rash or itching.

• Fluid retention or mild swelling.

• Tiredness or fatigue.

Serious side effects, though rare, include:

• Stomach ulcers or bleeding, which can cause severe abdominal pain, dark stools, or vomiting blood.

• Kidney problems, such as decreased urination, swelling of the legs, or ankle.

• Heart problems, such as high blood pressure, heart attack, or stroke, particularly with long-term use.

• Severe allergic reactions: Rash, itching, swelling, difficulty breathing.

• Liver problems: Yellowing of the skin or eyes, dark urine, persistent nausea.

If any of these serious side effects occur, seek medical attention immediately.

Contraindications:

Ibuprofen (Rheuxan) 400mg tablets should not be used in the following conditions:

1. Hypersensitivity to Ibuprofen or any other components of the formulation, especially if you have had allergic reactions to other NSAIDs (such as aspirin).

2. Active gastrointestinal bleeding or ulceration (stomach or intestinal ulcers, gastrointestinal bleeding).

3. Severe kidney disease or liver disease.

4. History of heart attack, stroke, or severe heart failure, as NSAIDs can increase the risk of cardiovascular events.

5. Pregnancy: Particularly in the third trimester, as NSAIDs may harm the developing fetus.

6. Severe dehydration or fluid imbalance, as this can exacerbate kidney problems with NSAIDs.

7. Asthma: Particularly if you have aspirin-sensitive asthma, as NSAIDs can cause asthma attacks or worsen the condition.

Warnings and Precautions:

• Gastrointestinal Risk: Ibuprofen may cause gastric ulcers or bleeding, especially with prolonged use. Take with caution in people with a history of ulcers or gastrointestinal disorders.

• Cardiovascular Risk: NSAIDs, including ibuprofen, may increase the risk of heart attack, stroke, and high blood pressure. Use the lowest effective dose for the shortest time possible, particularly in individuals with cardiovascular risk factors.

• Kidney Function: Prolonged use of ibuprofen may cause kidney damage, especially in people with pre-existing kidney conditions or those who are dehydrated.

• Pregnancy and Breastfeeding: Ibuprofen is generally not recommended during the third trimester of pregnancy, as it can harm the fetus. It should be used during pregnancy only if absolutely necessary, and the potential risks to the baby must be considered. It is excreted in breast milk, so consult your doctor before use during breastfeeding.

Drug Interactions:

Ibuprofen (Rheuxan) may interact with the following medications:

• Blood thinners (e.g., warfarin): Increased risk of bleeding.

• Diuretics (water pills), ACE inhibitors, or ARBs: Increased risk of kidney damage.

• Other NSAIDs or Aspirin: Increased risk of gastrointestinal bleeding or ulcers.

• Antihypertensive medications: Ibuprofen may reduce the effectiveness of blood pressure-lowering drugs.

• Lithium: Ibuprofen can increase the levels of lithium in the blood, which may lead to toxicity.

• Methotrexate: Can increase the toxicity of methotrexate, particularly in higher doses.

Always inform your healthcare provider about all medications, including over-the-counter drugs and herbal supplements, before using Ibuprofen (Rheuxan).

Storage:

• Store Ibuprofen (Rheuxan) tablets at room temperature (15°C to 30°C).

• Keep in a dry place, away from moisture and direct sunlight.

• Keep the medication out of the reach of children.

Conclusion:

Ibuprofen (Rheuxan) 400mg tablets are an effective treatment for pain, inflammation, and fever. They are commonly used for conditions such as headaches, arthritis, muscle pain, and menstrual cramps. However, they should be used cautiously in people with certain conditions like heart disease, kidney problems, and gastric ulcers. Always follow your doctor’s instructions regarding dosage and duration of use, and be aware of potential side effects, particularly with long-term use.